Publications

Publications

2017

Ando H, Yoshinaha T, Yamamoto W, Asakura K, Uda T, Taniguchi T, Ojima A, Shinkyo R, Kikuchi K, Osada T, Hayashi S, Kasai C, Miyamoto H, Yamazaki D, Sugiyama A, Kanda Y, Sawada K, Sekino Y. (2017) A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes. Journal of Pharmacological and Toxicological Methods 84: 111-127. doi: 0.1016/j.vascn.2016.12.003. Available here.

2016

Blinova, K., Stohlman, J., Vicente, J., Chan, D., Johannesen, L., Hortigon-Vinagre, MP., Zamora, V., Smith, G., Crumb, WJ., Pang, L., Lyn-Cook, B., Ross, J., Brock, B., Chvatal, S., Millard, D., Galeotti, D., Stockbridge, D., Strauss, DG. (2016) Comprehensive Translational Assessment of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias. Toxicological Sciences. doi: 10.1093/toxsci/kfw200. Advanced access here.
Colatsky, T., Fermini, B., Gintant, G., Pierson, J., Sager, P., Sekino, Y., Strauss, D., Stockbridge, N. (2016) The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress. Journal of Pharmacological and Toxicological Methods. 81:15-20. doi: 10.1016/j.vascn.2016.06.002. Open access download here.
Crumb, WJ., Vicente, J., Johannesen, L., Strauss, DG. (2016) An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel. Journal of Pharmacological and Toxicological Methods. In press. Preprint available here. Supplement available here.
Dutta, S., Strauss, D, Colatsky, T. Li, Z. (2016) Optimization of an In Silico Cardiac Cell Model for Proarrhythmia Risk Assessment. Computing in Cardiology. 43; doi:10.22489/CinC.2016.253-483. Available here.
Gintant, G., Sager, PT., Stockbridge, N. (2016). Evolution of strategies to improve preclinical cardiac safety testing. Nature Reviews Drug Discovery. 15: 457. Available here.
Johannesen, L., Vicente, J., Hosseini, M., Strauss, D.G. (2016) Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk. PLOS ONE, available online December 30, 2016, DOI:10.1371/journal.pone.0166925. Available here.
Li, Z., Dutta, S., Sheng, J., Tran, PN., Wu, W., Cotalsky, T. (2016) A temperature-dependent in silico model of the human ether-à-go-go-related (hERG) gene channel. Journal of Pharmacological and Toxicological Methods. 81, 233-239. doi: 10.1016/j.vascn.2016.05.005. Available here.
Vicente, J., Johannesen, L., Hosseini, M., Mason, J.W., Sager, P.T., Pueyo, E., Strauss, D.G. (2016) Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block. PLOS ONE, available online December 30, 2016, DOI: 10.1371/journal.pone.0163619. Available here.
Yamamoto W, Asakura K, Ando H, Taniguchi T, Ojima A, Uda T, Osada T, Hayashi S, Kasai C, Miyamoto N, Tashibu H, Yoshinaha T, Yamazaki D, Sugiyama A, Kanda Y, Sawada K, Sekino Y. (2016) Electrophysiological Characteristics of Human
iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential. PLoS ONE 11(12): e0167348. doi:10.1371/journal. pone.0167348. Available here.

2015

Fermini B, Hancox JC, Abi-Gerges N, Bridgland-Taylor M, Chaudhary KW, Colatsky T, Correll K, Crumb W, Damiano B, Erdemli G, Gintant G, Imredy J, Koerner J, Kramer J, Levesque P, Li Z, Lindqvist A, Obejero-Paz CA, Rampe D, Sawada K, Strauss DG, Vandenberg JI. (2015) A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm. J Biomol Screen. 21(1):1-11. doi: 10.1177/1087057115594589. Available here.
Johannesen, L., Vicente, J., Mason, JW., Erato, C., Sanabria, C., Waite-Labott, K., Hong, M., Lin, J., Guo, P., Mutlib, A., Wang, J., Crumb, WJ., Blinova, K., Chan, D., Stohlman, J., Florian, J., Ugander, M., Stockbridge, N., Strauss, DG. (2015) Late Sodium Current Block for Drug-Induced Long QT Syndrome: Results From a Prospective Clinical Trial. Clinical Pharmacology and Therapeutics. 99; 2. Available here.
Vicente, J., Johannesen, L., Mason, JW., Crumb, WJ., Pueyo, E., Stockbridge, N., Strauss, DG. (2015) Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil. Journal of the American Heart Association. doi: 10.1161/JAHA.114.001615. Available here.

2014

Johannesen, L., Vicente, J., Mason, JW., Sanabria, C., Waite-Labott, K., Hong, M., Guo, P., Lin, J., Sorensen, JS., Galeotti, L., Florian, J., Ugander, M., Stockbridge, N., Strauss, DG. (2014) Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil. Clinical pharmacology & Therapeutics. 96, 549-558. doi: 10.1038/clpt.2014.155. Available here.
Sager, P.T., Gintant, G., Turner, J.R., Pettit, S., Stockbridge, N. (2014) Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium. American Heart Journal. 167:3, 292-300. Open Access download here.